Combined effect of age and severity on the risk of dementia in Parkinson's disease
Identifieur interne : 001922 ( Main/Exploration ); précédent : 001921; suivant : 001923Combined effect of age and severity on the risk of dementia in Parkinson's disease
Auteurs : Gilberto Levy ; Nicole Schupf [États-Unis] ; Ming-Xin Tang [États-Unis] ; Lucien J. Cote ; Elan D. Louis ; Helen Mejia ; Yaakov Stern [États-Unis] ; Karen Marder [États-Unis]Source :
- Annals of Neurology [ 0364-5134 ] ; 2002-06.
Abstract
Age and severity of extrapyramidal signs have been consistently associated with incident dementia in Parkinson's disease. We evaluated the separate and combined effects of age and severity of extrapyramidal signs on the risk of incident dementia in Parkinson's disease in the setting of a population‐based prospective cohort study. Age and the total Unified Parkinson's Disease Rating Scale motor score at baseline evaluation were dichotomized at the median. Four groups of Parkinson's disease patients were defined: younger age/low severity (reference), younger age/high severity, older age/low severity, and older age/high severity. Risk ratios for incident dementia were calculated with Cox proportional hazards models controlling for gender, education, ethnicity, and duration of Parkinson's disease. Of 180 patients, 52 (28.9%) became demented during a mean follow‐up period of 3.6 ± 2.2 years. The median age at baseline of the Parkinson's disease patients was 71.8 years (range, 38.5–95.9 years), and the median total Unified Parkinson's Disease Rating Scale motor score was 24 (range, 2–65). The group with older age/high severity had a significantly increased risk of incident dementia (relative risk, 9.7; 95% confidence interval, 3.9–24.4) compared with the group with younger age/low severity (reference), whereas the groups with older age/low severity (relative risk, 1.6; 95% confidence interval, 0.5–4.8) and younger age/high severity (relative risk, 1.2; 95% confidence interval, 0.5–3.2) did not. These findings suggest that the increased risk of incident dementia in Parkinson's disease associated with age and severity of extrapyramidal signs is related primarily to their combined effect rather than separate effects.
Url:
DOI: 10.1002/ana.10219
Affiliations:
Links toward previous steps (curation, corpus...)
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Combined effect of age and severity on the risk of dementia in Parkinson's disease</title><author><name sortKey="Levy, Gilberto" sort="Levy, Gilberto" uniqKey="Levy G" first="Gilberto" last="Levy">Gilberto Levy</name></author><author><name sortKey="Schupf, Nicole" sort="Schupf, Nicole" uniqKey="Schupf N" first="Nicole" last="Schupf">Nicole Schupf</name></author><author><name sortKey="Tang, Ming In" sort="Tang, Ming In" uniqKey="Tang M" first="Ming-Xin" last="Tang">Ming-Xin Tang</name></author><author><name sortKey="Cote, Lucien J" sort="Cote, Lucien J" uniqKey="Cote L" first="Lucien J." last="Cote">Lucien J. Cote</name></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name></author><author><name sortKey="Mejia, Helen" sort="Mejia, Helen" uniqKey="Mejia H" first="Helen" last="Mejia">Helen Mejia</name></author><author><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name></author><author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:B0F2FEFEFB359DABFA83451D564B46A62585A378</idno><date when="2002" year="2002">2002</date><idno type="doi">10.1002/ana.10219</idno><idno type="url">https://api.istex.fr/document/B0F2FEFEFB359DABFA83451D564B46A62585A378/fulltext/pdf</idno><idno type="wicri:Area/Main/Corpus">000269</idno><idno type="wicri:Area/Main/Curation">000223</idno><idno type="wicri:Area/Main/Exploration">001922</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Combined effect of age and severity on the risk of dementia in Parkinson's disease</title><author><name sortKey="Levy, Gilberto" sort="Levy, Gilberto" uniqKey="Levy G" first="Gilberto" last="Levy">Gilberto Levy</name><affiliation><wicri:noCountry code="no comma">Gertrude H. Sergievsky Center and</wicri:noCountry></affiliation></author><author><name sortKey="Schupf, Nicole" sort="Schupf, Nicole" uniqKey="Schupf N" first="Nicole" last="Schupf">Nicole Schupf</name><affiliation><wicri:noCountry code="no comma">Gertrude H. Sergievsky Center and</wicri:noCountry></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York</wicri:cityArea></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>New York State Institute for Basic Research in Developmental Disabilities, Staten Island</wicri:cityArea></affiliation></author><author><name sortKey="Tang, Ming In" sort="Tang, Ming In" uniqKey="Tang M" first="Ming-Xin" last="Tang">Ming-Xin Tang</name><affiliation><wicri:noCountry code="no comma">Gertrude H. Sergievsky Center and</wicri:noCountry></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="subField">School of Public Health Departments of</wicri:noCountry></affiliation></author><author><name sortKey="Cote, Lucien J" sort="Cote, Lucien J" uniqKey="Cote L" first="Lucien J." last="Cote">Lucien J. Cote</name><affiliation><wicri:noCountry code="no comma">Neurology and</wicri:noCountry></affiliation></author><author><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><affiliation><wicri:noCountry code="no comma">Gertrude H. Sergievsky Center and</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="no comma">Neurology and</wicri:noCountry></affiliation></author><author><name sortKey="Mejia, Helen" sort="Mejia, Helen" uniqKey="Mejia H" first="Helen" last="Mejia">Helen Mejia</name><affiliation><wicri:noCountry code="no comma">Gertrude H. Sergievsky Center and</wicri:noCountry></affiliation><affiliation><wicri:noCountry code="no comma">Neurology and</wicri:noCountry></affiliation></author><author><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><affiliation><wicri:noCountry code="no comma">Gertrude H. Sergievsky Center and</wicri:noCountry></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="no comma">Neurology and</wicri:noCountry></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Psychiatry, College of Physicians and Surgeons, Columbia University, New York</wicri:cityArea></affiliation></author><author><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><affiliation><wicri:noCountry code="no comma">Gertrude H. Sergievsky Center and</wicri:noCountry></affiliation><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><placeName><region type="state">État de New York</region></placeName><wicri:cityArea>Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University, New York</wicri:cityArea></affiliation><affiliation><wicri:noCountry code="no comma">Neurology and</wicri:noCountry></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of Neurology</title><title level="j" type="sub">Official Journal of the American Neurological Association and the Child Neurology Society</title><title level="j" type="abbrev">Ann Neurol.</title><idno type="ISSN">0364-5134</idno><idno type="eISSN">1531-8249</idno><imprint><publisher>Wiley Subscription Services, Inc., A Wiley Company</publisher><pubPlace>New York</pubPlace><date type="published" when="2002-06">2002-06</date><biblScope unit="volume">51</biblScope><biblScope unit="issue">6</biblScope><biblScope unit="page" from="722">722</biblScope><biblScope unit="page" to="729">729</biblScope></imprint><idno type="ISSN">0364-5134</idno></series><idno type="istex">B0F2FEFEFB359DABFA83451D564B46A62585A378</idno><idno type="DOI">10.1002/ana.10219</idno><idno type="ArticleID">ANA10219</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0364-5134</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Age and severity of extrapyramidal signs have been consistently associated with incident dementia in Parkinson's disease. We evaluated the separate and combined effects of age and severity of extrapyramidal signs on the risk of incident dementia in Parkinson's disease in the setting of a population‐based prospective cohort study. Age and the total Unified Parkinson's Disease Rating Scale motor score at baseline evaluation were dichotomized at the median. Four groups of Parkinson's disease patients were defined: younger age/low severity (reference), younger age/high severity, older age/low severity, and older age/high severity. Risk ratios for incident dementia were calculated with Cox proportional hazards models controlling for gender, education, ethnicity, and duration of Parkinson's disease. Of 180 patients, 52 (28.9%) became demented during a mean follow‐up period of 3.6 ± 2.2 years. The median age at baseline of the Parkinson's disease patients was 71.8 years (range, 38.5–95.9 years), and the median total Unified Parkinson's Disease Rating Scale motor score was 24 (range, 2–65). The group with older age/high severity had a significantly increased risk of incident dementia (relative risk, 9.7; 95% confidence interval, 3.9–24.4) compared with the group with younger age/low severity (reference), whereas the groups with older age/low severity (relative risk, 1.6; 95% confidence interval, 0.5–4.8) and younger age/high severity (relative risk, 1.2; 95% confidence interval, 0.5–3.2) did not. These findings suggest that the increased risk of incident dementia in Parkinson's disease associated with age and severity of extrapyramidal signs is related primarily to their combined effect rather than separate effects.</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>État de New York</li></region></list><tree><noCountry><name sortKey="Cote, Lucien J" sort="Cote, Lucien J" uniqKey="Cote L" first="Lucien J." last="Cote">Lucien J. Cote</name><name sortKey="Levy, Gilberto" sort="Levy, Gilberto" uniqKey="Levy G" first="Gilberto" last="Levy">Gilberto Levy</name><name sortKey="Louis, Elan D" sort="Louis, Elan D" uniqKey="Louis E" first="Elan D." last="Louis">Elan D. Louis</name><name sortKey="Mejia, Helen" sort="Mejia, Helen" uniqKey="Mejia H" first="Helen" last="Mejia">Helen Mejia</name></noCountry><country name="États-Unis"><region name="État de New York"><name sortKey="Schupf, Nicole" sort="Schupf, Nicole" uniqKey="Schupf N" first="Nicole" last="Schupf">Nicole Schupf</name></region><name sortKey="Marder, Karen" sort="Marder, Karen" uniqKey="Marder K" first="Karen" last="Marder">Karen Marder</name><name sortKey="Schupf, Nicole" sort="Schupf, Nicole" uniqKey="Schupf N" first="Nicole" last="Schupf">Nicole Schupf</name><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><name sortKey="Stern, Yaakov" sort="Stern, Yaakov" uniqKey="Stern Y" first="Yaakov" last="Stern">Yaakov Stern</name><name sortKey="Tang, Ming In" sort="Tang, Ming In" uniqKey="Tang M" first="Ming-Xin" last="Tang">Ming-Xin Tang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/ParkinsonV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001922 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001922 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= ParkinsonV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:B0F2FEFEFB359DABFA83451D564B46A62585A378
|texte= Combined effect of age and severity on the risk of dementia in Parkinson's disease
}}
| This area was generated with Dilib version V0.6.23. |  |